Novel Approaches for Inhibition of Mucus Hypersecretion in Asthma

Author(s): Anurag Agrawal, Ulaganathan Mabalirajan, Arjun Ram, Balaram Ghosh

Journal Name: Recent Patents on Inflammation & Allergy Drug Discovery

Volume 1 , Issue 3 , 2007

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Many obstructive airway disorders such as cystic fibrosis, asthma, and chronic obstructive pulmonary disease (COPD) are characterized by mucous metaplasia of the airway epithelium and chronic mucus hypersecretion. Airway occlusion by mucus plugging has been reported in many cases of fatal asthma and conventional mucolytic therapies have been unable to significantly affect mucus-related airway obstruction. Recently, for the first time, direct evidence was presented for improvement of mucus related airway obstruction in a murine model of asthma, highlighting the potential usefulness of therapeutically targeting mucus hypersecretion. We review the emerging targets for inhibition of mucus hypersecretion and discuss some of the recent published scientific literature and patent applications in this field, to provide a framework for further drug discovery in mucus modulation.

Keywords: Asthma, COPD, mucin, airway inflammation, airway hyperresponsiveness

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Article Details

Year: 2007
Page: [188 - 192]
Pages: 5
DOI: 10.2174/187221307782418865
Price: $65

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