Abstract
The gastrointestinal tract has a crucial role in the control of energy homeostasis through the action of multiple peptides known as incretins that act on distant target sites to promote the efficient uptake and storage of energy. In particular, GLP-1, an incretin hormone secreted from the intestinal mucosa in response to meal ingestion, is shown to augment the magnitude of meal-stimulated insulin secretion from islet β cells in a glucose-dependent manner and thus proved to be a novel candidate for treatment in patients with diabetes mellitus. This article reviews the biological actions of GLP-1 regulating glucose homeostasis, with an emphasis on mechanisms of action and the emerging therapeutic roles of GLP-1 analogues, and DPP-4 inhibitors for the treatment of diabetes mellitus.
Keywords: GLP-1 analogues, DPP-4 Inhibitors, diabetes mellitus
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
Title: GLP-1 as a Therapeutic Agent in Patients with Type 2 Diabetes Mellitus
Volume: 1 Issue: 3
Author(s): Ioannis Legakis
Affiliation:
Keywords: GLP-1 analogues, DPP-4 Inhibitors, diabetes mellitus
Abstract: The gastrointestinal tract has a crucial role in the control of energy homeostasis through the action of multiple peptides known as incretins that act on distant target sites to promote the efficient uptake and storage of energy. In particular, GLP-1, an incretin hormone secreted from the intestinal mucosa in response to meal ingestion, is shown to augment the magnitude of meal-stimulated insulin secretion from islet β cells in a glucose-dependent manner and thus proved to be a novel candidate for treatment in patients with diabetes mellitus. This article reviews the biological actions of GLP-1 regulating glucose homeostasis, with an emphasis on mechanisms of action and the emerging therapeutic roles of GLP-1 analogues, and DPP-4 inhibitors for the treatment of diabetes mellitus.
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Cite this article as:
Legakis Ioannis, GLP-1 as a Therapeutic Agent in Patients with Type 2 Diabetes Mellitus, Recent Patents on Endocrine, Metabolic & Immune Drug Discovery 2007; 1 (3) . https://dx.doi.org/10.2174/187221407782409107
DOI https://dx.doi.org/10.2174/187221407782409107 |
Print ISSN 1872-2148 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3334 |
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