A Role for Leptin in the Systemic Inflammatory Response Syndrome (SIRS) and in Immune Response

Author(s): W. Waelput, P. Brouckaert, D. Broekaert, J. Tavernier

Journal Name: Current Drug Targets - Inflammation & Allergy
Continued as Inflammation & Allergy - Drug Targets

Volume 1 , Issue 3 , 2002


Leptin was originally identified as an adipocyte-derived cytokine with a key role in the regulation of the energy balance. Subsequent research has, however, revealed that leptins biological action is not restricted to its effects on appetite and food intake, but rather has a much more pleiotropic character. Evidence is now accumulating that it has important functions in reproduction, hematopoiesis, HPA-axis endocrinology and angiogenesis. In this review, we have focused on the effects of leptin in the immune system, which can be found in both the antigen-specific immunity and in the inflammatory effector system.

Keywords: Leptin, Systemic Inflammatory Response Syndrome (SIRS), Immune Response, STARVATION, CELL IMMUNITY

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Article Details

Year: 2002
Published on: 01 March, 2012
Page: [277 - 289]
Pages: 13
DOI: 10.2174/1568010023344634
Price: $65

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