Chlamydial Heat Shock Protein 60 and Lipopolysaccharide: Potential Virulence Determinants in Atherogenesis

Author(s): Murat V. Kalayoglu

Journal Name: Current Drug Targets - Inflammation & Allergy
Continued as Inflammation & Allergy - Drug Targets

Volume 1 , Issue 3 , 2002


Chlamydia pneumoniae infection is associated with atherosclerosis and may be an emerging risk factor in coronary artery disease. C. pneumoniae can infect, multiply within and modulate the function of all atheroma cell types. Specific chlamydial virulence determinants have been identified that permit interaction with host cells and dysregulate cell function. In particular, chlamydial heat shock protein 60 and lipopolysaccharide may modulate cell function to dysregulate lipid metabolism, induce inflammatory cytokine cascades and trigger production of cross-reactive antibodies that initiate and promote atherogenesis. This paper reviews chlamydial heat shock protein 60 and lipopolysaccharide as potential virulence determinants in atherogenesis.

Keywords: Chlamydial, Protein, Lipopolysaccharide, Atherogenesis, ATHEROSCLEROSIS

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Article Details

Year: 2002
Page: [249 - 255]
Pages: 7
DOI: 10.2174/1568010023344652
Price: $65

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