Controlling Bacterial Infection by Inhibiting Intercellular Signalling

Author(s): M. Manefield, S. Kjelleberg, M. Givskov

Journal Name: Current Medicinal Chemistry - Anti-Infective Agents
Continued as Anti-Infective Agents

Volume 2 , Issue 3 , 2003


The opportunistic human pathogen Pseudomonas aeruginosa, which causes fatal lung infections in cystic fibrosis patients, regulates the expression of virulence factors by N-acyl-Lhomoserine lactone (AHL) mediated gene expression. AHL mediated gene expression, also known as quorum sensing, involves the production of and response to a small diffusible metabolite. This gene expression mechanism allows populations of P. aeruginosa to coordinate expression of virulence factors to maximise the success of infection. AHL mediated gene expression offers a new target for the control of bacterial infection that is not dependent on the use of compounds with antibiotic activity. This review summarises investigations that have demonstrated the efficacy of marine natural products in inhibiting AHL mediated gene expression and controlling P. aeruginosa infection.

Keywords: quorum sensing, delisea, homoserine lactone, infection, pseudomonas aeruginosa

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Article Details

Year: 2003
Page: [213 - 218]
Pages: 6
DOI: 10.2174/1568012033483033
Price: $58

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