Amyloids, Aggregates and Neuronal Inclusions: Good or Bad News for Neurons?

Author(s): Hyoung-gon Lee, Xiongwei Zhu, Robert B. Petersen, George Perry, Mark A. Smith

Journal Name: Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents
Continued as Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry

Volume 3 , Issue 4 , 2003


Protein aggregation and misfolding are two of the pathological hallmarks that are common to many neurodegenerative diseases including Alzheimer disease, Parkinson disease and Huntington disease. While it has generally been assumed that protein aggregation is responsible for neurodegeneration in these disorders, we suspect that protein aggregation, rather than being a major killer of neurons, is, in fact, an attempt to protect neurons from stressful, disease-causing conditions. In this review, we weigh the evidence of whether amyloids, aggregates and neuronal inclusions are good or bad news for neurons.

Keywords: protein aggregation, amlyoid, alzheimer disease, parkinson disease, Huntington disease, neurodegeneration, neuroprotection

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Article Details

Year: 2003
Published on: 01 March, 2012
Page: [293 - 298]
Pages: 6
DOI: 10.2174/1568013033483221
Price: $65

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