Title: Serotonin Type-4 (5-HT4) Receptors as Therapeutic Targets: 5-HT4 Receptor Antagonists
VOLUME: 3 ISSUE: 1
Author(s):Henri Mattes and Hans-Juergen Pfannkuche
Affiliation:Research Department, Novartis Ophthalmics AG, CH-4002 Basel, Switzerland NS Research, Novartis Pharma AG, CH-4002 Basel, Switzerland
Keywords:5-ht4 receptor, 5-ht4 receptor antagonist, serotonin antagonist
Abstract: Characterization of 5-HT 4 receptors started in the late eighties following the important finding that the potent 5-HT3 receptor antagonist, tropisetron, could act as a competitive antagonist at the newly discovered 5-HT4 receptor. During recent years several pharmaceutical companies claimed that their 5-HT4 antagonists might be useful for the treatment and / or prophylaxis of cardiovascular, CNS and gastrointestinal disorders. This paper reviews the development of 5-HT4 receptor antagonists from experimental tools towards potential therapeutic agents.
