Title: Antifolates - Past, Present and Future
VOLUME: 4 ISSUE: 5
Author(s):Aleem Gangjee and Hiteshkumar D. Jain
Affiliation:Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282.
Keywords:thymidylate synthase (ts), dihydrofolate reductase (dhfr), antifolates, classical, nonclassical, inhibitors
Abstract: This short perspective briefly covers selected aspects of the past, present and future of antifolates in chemotherapy. Both classical and nonclassical analogs currently in the preclinical stage and clinically used agents are covered.
