CD8+ T cells are strong mediators of antiviral responses. In addition to lysis of HIV infected cells, CD8+ T cells produce proteins which inhibit HIV replication by non-lytic mechanisms. These proteins include β-chemokines which inhibit viral entry and IL-16 which inhibits HIV transcription. The CD8+ T cell antiviral factor (CAF) also inhibits HIV transcription. CAF remains unidentified. This update summarizes the research conducted over the last two years pertaining to CD8+ T cell antiviral activity.
Keywords: cd8, t cell, defensin, hiv-1 transcription, replication
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