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Medicinal Chemistry Reviews - Online (Discontinued)

Editor-in-Chief

ISSN (Print): 1567-2034
ISSN (Online): 1567-2034

The Role of CD8+ T Cell Soluble Factors in Human Immunodeficiency Virus Infection: An Update

Author(s): Karen F.T. Copeland

Volume 1, Issue 1, 2004

Page: [11 - 12] Pages: 2

DOI: 10.2174/1567203043480421

Abstract

CD8+ T cells are strong mediators of antiviral responses. In addition to lysis of HIV infected cells, CD8+ T cells produce proteins which inhibit HIV replication by non-lytic mechanisms. These proteins include β-chemokines which inhibit viral entry and IL-16 which inhibits HIV transcription. The CD8+ T cell antiviral factor (CAF) also inhibits HIV transcription. CAF remains unidentified. This update summarizes the research conducted over the last two years pertaining to CD8+ T cell antiviral activity.

Keywords: cd8, t cell, defensin, hiv-1 transcription, replication


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