Toward the Design of MR Agents for Imaging β-Cell Function

Author(s): Mark Woods, Shanrong Zhang, A. Dean Sherry

Journal Name: Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents
Continued as Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry

Volume 4 , Issue 4 , 2004


The chemistry of Gd3+-based MRI agents has advanced considerably during the past decade toward agents with higher relaxivity and agents that respond to physiology and / or metabolism. This review describes various approaches that have been taken toward the development of responsive contrast agents and discusses the importance of fast water exchange for advancement of targeted Gd3+-based agents with higher sensitivity. The recent discovery of Eu3+ complexes having extraordinarily slow water exchange has opened a new avenue in contrast agent design based upon the chemical exchange saturation transfer (CEST) mechanism. These new paramagnetic complexes called PARACEST agents offer new possibilities of imaging biological functions such as tissue pH and metabolite levels. The lower detection limits that may apply to each class of contrast agent (Gd3+-based versus PARACEST) are discussed and the extent to which they may be applied to the imaging of β-cells is considered.

Keywords: magnetic resonance imaging, targeted contrast agents, responsive contrast agents, b-cells

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Article Details

Year: 2004
Page: [349 - 369]
Pages: 21
DOI: 10.2174/1568013043357338
Price: $58

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