Title: Chemokines and Chemokine Receptors as Targets in the Therapy of Psoriasis
VOLUME: 3 ISSUE: 2
Author(s):Bernhard Homey
Affiliation:Dept. of Dermatology,Heinrich-Heine-University, Moorenstr.5, 40225 Düsseldorf, Germany.
Keywords:chemokines, chemokine receptors, psoriasis, therapy, ccr4, ccr6, cccr10, cxcr3
Abstract: Chemokines are members of a superfamily of small, cytokine-like, chemotactic proteins that have recently been shown to critically regulate leukocyte trafficking. Accumulating evidence indicates that the chronically relapsing inflammatory skin disease psoriasis represents a T cell-mediated disease. Thus, the understanding of the underlying mechanisms of memory T cell homing to the skin may provide promising targets for the development of novel therapeutics. Here results of recent studies associating chemokines with a psoriatic phenotype and delineating their role in the recruitment of memory T cells to the skin are discussed.
