T-Cell-Targeted Biologicals for Psoriasis

Author(s): Christopher E.M. Griffiths

Journal Name: Current Drug Targets - Inflammation & Allergy
Continued as Inflammation & Allergy - Drug Targets

Volume 3 , Issue 2 , 2004


Abstract:

Psoriasis is now accepted as a T-cell-mediated disease and that targeting of T cell function and / or trafficking is a logical approach to therapy. As a consequence of recombinant DNA technologies biologic therapies are synthesisable in sufficient quantities for clinical use. The original proof of concept for T-celltargeted therapies in psoriasis came with the demonstration that anti-CD4 monoclonal antibodies were effective. Progress is such that two T-cell-directed biologicals - alefacept and efalizumab - have recently been approved in the U.S.A. for the treatment of psoriasis. In addition to providing new therapies the T-cell-targeted biologicals with their selective approach can be used as sophisticated tools to dissect out and help our understanding of key pathomechanisms in psoriasis; the non - efficacy of anti - E-selectin is a case in point. It is likely that the most appropriate place for T-cell-directed biologicals in the management of chronic plaque psoriasis will be for maintenance, rather than induction, of remission. This is a reflection of mode of action and relative safety for long-term administration.

Keywords: anti-cd4, anti-cd25, efalizumab, alefacept, anti-cd28, e-selectin

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Article Details

VOLUME: 3
ISSUE: 2
Year: 2004
Published on: 01 March, 2012
Page: [157 - 161]
Pages: 5
DOI: 10.2174/1568010043343912
Price: $65

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