Antioxidants in Peripheral Arterial Disease

Author(s): F. Violi, L. Loffredo, A. Marcoccia

Journal Name: Current Drug Targets - Cardiovascular & Hematological Disorders
Continued as Cardiovascular & Hematological Disorders-Drug Targets

Volume 4 , Issue 3 , 2004

Abstract:

Peripheral arterial disease (PAD) is an important manifestation of systemic atherosclerosis that is characterized by obstruction of the arteries in the lower limbs. Experimental and epidemiological studies suggest a key role for oxidative stress in initiation and progression of the atherosclerotic process. The results of these studies provided a good basis for interventional trials with antioxidants, particularly with vitamin E, but the findings were conflicting. In this paper we review the observational and interventional studies with antioxidants, and ask whether vitamin supplementation should be recommended for PAD patients.

Keywords: peripheral arterial disease, oxidative stress, antioxidants, atherosclerosis

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Article Details

VOLUME: 4
ISSUE: 3
Year: 2004
Page: [289 - 294]
Pages: 6
DOI: 10.2174/1568006043336212
Price: $58

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