Complement: An Inflammatory Pathway Fulfilling Multiple Roles at the Interface of Innate Immunity and Development

Author(s): D. Mastellos, A. E. Germenis, J. D. Lambris

Journal Name: Current Drug Targets - Inflammation & Allergy
Continued as Inflammation & Allergy - Drug Targets

Volume 4 , Issue 1 , 2005


Abstract:

Complement has been long perceived as an innate immune system that plays a pivotal role in the maintenance of host defense against infectious agents and the propagation of pro-inflammatory responses in the context of human disease. Complement activation has been associated with the onset of acute inflammatory reactions leading to complications such as acute graft rejection, local tissue injury and multiorgan failure. However, recent studies have indicated that various complement activation products may exert a beneficial effect by contributing

Keywords: Immunity, proteins, multiorgan

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Article Details

VOLUME: 4
ISSUE: 1
Year: 2005
Published on: 01 March, 2012
Page: [125 - 127]
Pages: 3
DOI: 10.2174/1568010053622993

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