Amyloidosis and Auto-Inflammatory Syndromes

Author(s): Gilles Grateau, Isabelle Jeru, Saad Rouaghe, Cecile Cazeneuve, Nathalie Ravet, Philippe Duquesnoy, Laurence Cuisset, Catherine Dode, Marc Delpech, Serge Amselem

Journal Name: Current Drug Targets - Inflammation & Allergy
Continued as Inflammation & Allergy - Drug Targets

Volume 4 , Issue 1 , 2005


Abstract:

Amyloidosis remains currently a severe potential complication of many chronic inflammatory disorders. It is not exactly know why some patients develop a progressive amyloidosis, whereas others do not although latent deposits may be present. A permanent acute phase response, ideally evaluated with serial measurement of serum protein SAA, the precursor of the AA protein deposited in tissues, seems to be a prerequisite to the development of inflammatory (AA) amyloidosis. Genetic factors have however been recently emphasized. Among persistent or emerging causes of AA amyloidosis, hereditary periodic fever syndromes also known as auto-inflammatory syndromes are a group of diseases characterised by intermittent bouts of clinical inflammation with focal organ involvement mainly: abdomen, musculoskeletal system and skin. The most frequent is familial Mediterranean fever which affects patients of Mediterranean descent all over the world. Three other types have been recently clinically as well as genetically characterised. A thorough diagnosis is warranted, as clinical and therapeutic management is specific for each of these diseases.

Keywords: Amyloidosis, musculoskeletal, Mediterranean fever

Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 4
ISSUE: 1
Year: 2005
Page: [57 - 65]
Pages: 9
DOI: 10.2174/1568010053622786
Price: $65

Article Metrics

PDF: 23