Stent-Based Delivered Anti-Proliferative Drugs in the Prevention of Coronary Stent Restenosis

Author(s): Raul Moreno, Carlos Macaya

Journal Name: Current Medicinal Chemistry - Cardiovascular & Hematological Agents
Continued as Cardiovascular & Hematological Agents in Medicinal Chemistry

Volume 3 , Issue 3 , 2005

Abstract:

Coronary stents are currently used in most percutaneous coronary interventions, since they have demonstrated to reduce restenosis and allow to solve threatened closure after balloon angioplasty. Despite these beneficial effects, restenosis remains as the main limitation of percutane ous coronary interventions even with the use of coronary stents. In the last 3 years, some coronary stents eluting anti-proliferative drugs have demonstrated to dramatically reduce the risk of restenosis. By November 2004, two different types of antiproliferative drugs eluted by coronary stents are commercially available: sirolimus (rapamycin) and paclitaxel. The mechanisms, clinical evidence, as well as the remaining limitations of these drug-eluting stents are reviewed. The current knowledge of other anti-proliferative drugs that are currently under investigation is also reviewed.

Keywords: coronary stent, anti-proliferative drug, sirolimus, paclitaxel, restenosis

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Article Details

VOLUME: 3
ISSUE: 3
Year: 2005
Page: [221 - 229]
Pages: 9
DOI: 10.2174/1568016054368160
Price: $58

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