Dopamine Receptor and Hypertension

Author(s): Chunyu Zeng, Gilbert M. Eisner, Robin A. Felder, Pedro A. Jose

Journal Name: Current Medicinal Chemistry - Cardiovascular & Hematological Agents
Continued as Cardiovascular & Hematological Agents in Medicinal Chemistry

Volume 3 , Issue 1 , 2005


Dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport and reactive oxygen and by interacting with vasopressin, renin-angiotensin, and the sympathetic nervous system. Decreased renal dopamine production and / or impaired dopamine receptor function have been reported in hypertension. Disruption of any of the dopamine receptors (D1, D2, D3, D4, and D5) results in hypertension. In this paper, we review the mechanisms by which hypertension develops when dopamine receptor function is perturbed.

Keywords: essential hypertension, dopamine receptor, g protein-coupled receptor kinase type 4, protein phosphotase 2a, endocytosis, desensitization, sodium excretion, vasorelaxation

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Article Details

Year: 2005
Page: [69 - 77]
Pages: 9
DOI: 10.2174/1568016052773289
Price: $65

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