Strategic Leukofiltration in Cardiac Surgery

Author(s): S. Gunaydin, K. McCusker, V. Vijay

Journal Name: Current Medicinal Chemistry - Cardiovascular & Hematological Agents
Continued as Cardiovascular & Hematological Agents in Medicinal Chemistry

Volume 3 , Issue 4 , 2005


Systemic inflammatory response syndrome (SIRS) with activation of molecular cascades, cell activation, accumulation of interstitial fluid, organ dysfunction and, occasionally, organ failure is still a commonly recognized consequence of cardiac surgery. SIRS leads to costly complications and several strategies intended to ameliorate the symptoms that have been studied, including leukocyte reduction, using filtration. Although, the body of work suggests that leukoreduction attenuates SIRS, discrepancies remain within the literature. The recent literature is reviewed highlighting the areas where concordance is lacking. In our study, on the basis of indirect indicators of SIRS, platelet function by thromboelastography biomaterial evaluation by light and scanning electron microscopy, we present our conclusions regarding clinical outcomes and the role of leukofiltration.

Keywords: cardiopulmonary bypass, coated materials-biocompatible, leukapheresis, reperfusion injury, leukocyte filtration, surface modifying additives

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Article Details

Year: 2005
Page: [323 - 331]
Pages: 9
DOI: 10.2174/156801605774322328
Price: $58

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