AMP-Activated Protein Kinase (AMPK): Regulation of Metabolic Gene Expression

Author(s): U. S. Varanasi

Journal Name: Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents
Continued as Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry

Volume 5 , Issue 5 , 2005


AMPK (AMP-activated protein kinase) is a serine/threonine kinase that functions as a metabolic master switch by regulating ATP consuming anabolic pathways and ATP generating catabolic pathways in response to cellular energy status. It is activated in response to stresses such as: diabetes, hypoxia, toxins, nutrient deprivation, hormones and drugs. Although most of the known functions of AMPK are due to regulation of metabolic enzyme activity in cytoplasm, a growing body of evidence suggests that AMPK also functions as major regulator of metabolic gene expression. Here I review our current understanding of how AMPK regulates gene expression at the transcriptional, mRNA stability, and protein synthesis levels.

Keywords: ampk, aicar, fkhr, hnf-a, chrebp, ppar, hur, importin a/b

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Article Details

Year: 2005
Page: [459 - 466]
Pages: 8
DOI: 10.2174/156801305774322457
Price: $65

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