Relaxin-Like Peptides in Neoplastic Lesions

Author(s): T. Klonisch, C. Hoang-Vu, S. Hombach-Klonisch

Journal Name: Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents
Continued as Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry

Volume 5 , Issue 5 , 2005


The two members of the relaxin family of insulin-like peptide hormones, relaxin and INSL3, and their cognate G protein coupled receptors LGR7 and LGR8, respectively, are present in human tumor tissues. Although the physiological role and signal transduction pathways engaged by relaxin-like members in tumor tissues are still largely unknown, novel data mainly obtained from in-vitro cellular models suggest that relaxin-like peptides influence cellular functions associated with motility and migration, cytoskeletal rearrangement and enzyme production and secretion. The expression of relaxin-like peptides appears to be regulated in a tumor-specific context by the actions of various nuclear receptors. This review summarizes most recent findings on the potential functions of relaxin/ INSL3 ligand-receptor systems in tumor tissues and follows an organ-specific approach.

Keywords: relaxin, insl, lgr, tumor biology, breast, prostate, thyroid, mtc

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Article Details

Year: 2005
Page: [431 - 437]
Pages: 7
DOI: 10.2174/156801305774322475
Price: $58

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