Water Transport into Bile and Role in Bile Formation

Author(s): Giuseppe Calamita, Domenico Ferri, Patrizia Gena, Giuseppa E. Liquori, Raul A. Marinelli, Giuliano Meyer, Piero Portincasa, Maria Svelto

Journal Name: Current Drug Targets - Immune, Endocrine & Metabolic Disorders
Continued as Endocrine, Metabolic & Immune Disorders - Drug Targets

Volume 5 , Issue 2 , 2005


Formation of bile and generation of bile flow are driven by the active secretion of bile salts (BS), lipids and electrolytes into the canalicular and bile duct lumens followed by the osmotic movement of water. Although the transporting proteins involved in solute secretion have been cloned and their coordinated interplay defined both in health and disease, boosted by the discovery of the aquaporin water channels, only recently has considerable attention been addressed to the mechanism by which water, the major component of bile ( > 95%), moves across the hepatobiliary epithelia. This review summarizes the novel acquisitions in liver membrane water transport and functional participation of aquaporin water channels in multiple aspects of hepatobiliary fluid balance. Emerging evidences suggesting involvement of aquaporins in the metabolic homeostasis of the hepatobiliary tract are also discussed.

Keywords: liver, canalicular secretion, ductal bile, water transport, bile salts, aquaporin, mitochondria

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Article Details

Year: 2005
Page: [137 - 142]
Pages: 6
DOI: 10.2174/1568005310505020137
Price: $65

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