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Current Medicinal Chemistry - Anti-Infective Agents

Editor-in-Chief

ISSN (Print): 1568-0126
ISSN (Online): 1875-600X

Recent Progress in the Discovery of New CCR5 and CXCR4 Chemokine Receptor Antagonists as Inhibitors of HIV-1 Entry. Part 2*

Author(s): Wieslaw M. Kazmierski, Jennifer P. Peckham, Maosheng Duan, Terry P. Kenakin, Stephen Jenkinson, Kristjan S. Gudmundsson, Stephen C. Piscitelli and Paul L. Feldman

Volume 4, Issue 2, 2005

Page: [133 - 152] Pages: 20

DOI: 10.2174/1568012053506981

Price: $65

Abstract

This review addresses key medicinal chemistry issues relevant in the discovery and development of CCR5 and CXCR4 antagonists as anti-HIV drugs. Recent progress in the discovery and development of such antagonists, SAR and clinical status are reviewed.

Keywords: chemotherapy, transcriptase inhibitors, aids, ccr5 receptor, probe, chemokine, allosteric modulator


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