CD8+ T-cells: Are They Sufficient to Prevent, Contain or Eradicate HIV-1 Infection?

Author(s): S. A. Brown, J. L. Hurwitz, X. Zhan, P. C. Doherty, K. S. Slobod

Journal Name: Current Drug Targets - Infectious Disorders
Continued as Infectious Disorders - Drug Targets

Volume 5 , Issue 2 , 2005


The prevention of HIV-1 by vaccination has proven to be a formidable task. In an ongoing endeavor to end the HIV-1 pandemic, scientists seek vaccines that will elicit quantitatively and qualitatively robust B-cell and T-cell activities. Given that cytotoxic T-lymphocytes (CTL) play a substantial role in the immunological control of immunodeficiency virus infections, this review will focus on vaccines designed to elicit HIV-1-specific CTL. Vaccine approaches using various HIV-1 proteins or specific CTL determinants, partnered with diverse delivery systems and adjuvants will be discussed. Lessons from studies with other virus models (e.g. gamma herpes virus and influenza virus) will also be examined. Since CTL contribute to the success of vaccines in other model systems, an understanding of the strengths and possible limitations of these cells may be critical to future successes in the HIV-1 vaccine field.

Keywords: cd t-cells, hiv vaccine, hiv prevention

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Article Details

Year: 2005
Page: [113 - 119]
Pages: 7
DOI: 10.2174/1568005054201571
Price: $58

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