DNAM-1 (CD226): A Two-Sword Fencer for Innate and Adaptive Immunity

Author(s): Akira Shibuya, Satoko Tahara-Hanaoka, Kazuko Shibuya

Journal Name: Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents
Continued as Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

Volume 4 , Issue 1 , 2005


The leukocyte adhesion molecule DNAM-1 (CD226) is a member of the immunoglobulin superfamily and constitutively expressed on the majority of CD4+ and CD8+ T lymphocytes, natural killer (NK) cells, monocytes / macrophages, platelets and megakaryocytes and a subset of B lymphocytes. The poliovirus receptor (CD155) and its family member nectin 2 (CD112) have recently been identified as the ligands for DNAM-1. Interaction of DNAM- 1 with the ligands induces NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. Upon antigen recognition by the T cell receptor, DNAM-1 physically associates with the αLβ2 integrin adhesion molecule LFA-1 and plays an essential role for LFA-1-mediated costimulatory signals for differentiation from naïve CD4+ T cells toward Th1 cells. Moreover, DNAM-1 is involved in macrophage and platelet activation and adhesion to vascular endothelial cells. Thus, DNAM-1 is involved in a variety of hematopoietic cell functions for innate and adaptive immunities.

Keywords: leukocyte adhesion molecule DNAM-1 (CD226), T cell-mediated cytotoxicity, macrophage, cytotoxicity, cytokine

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Article Details

Year: 2005
Page: [53 - 58]
Pages: 6
DOI: 10.2174/1568014053005390

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