Pathophysiology of Tension-Type Headache: Potential Drug Targets

Author(s): Messoud Ashina

Journal Name: CNS & Neurological Disorders - Drug Targets
Formerly Current Drug Targets - CNS & Neurological Disorders

Volume 6 , Issue 4 , 2007

Become EABM
Become Reviewer
Call for Editor


The pathophysiology of tension-type headache is still far from clear, although recent advances in basic and clinical research have increased our knowledge about mechanisms underlying this disorder. Experimental studies suggest that increased excitability of the CNS generated by repetitive and sustained pericranial myofascial input may be responsible for transformation of episodic tension-type headache into chronic form. Future studies should focus on the identification of the source of peripheral nociception in patients with tension-type headache and the development of more effective and specific treatment modalities.

Keywords: Chronic tension-type headache, CNS, NOS inhibitors, antinociceptive, NO donor glyceryl trinitrate

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2007
Page: [238 - 239]
Pages: 2
DOI: 10.2174/187152707781387297
Price: $65

Article Metrics

PDF: 5