cAMP-Mediated Regulation of CYP Enzymes and Its Application in Chemotherapy

Title: cAMP-Mediated Regulation of CYP Enzymes and Its Application in Chemotherapy

Volume: 1 Issue: 3

Author(s): Yoshihiro Ishikawa, Sayaka Suzuki, Koji Otsu, Coskun Ulucan, Kousaku Iwatsubo and Haruki Eguchi

Affiliation:

Keywords: Cytochrome P450, protein kinase A, adenylyl cyclase, phosphorylation, forskolin, anti-cancer drugs

Abstract: Certain anti-cancer prodrugs are subject to cytochrome P450 (CYP)-mediated metabolism and become more active. Because CYP activity may be regulated by phosphorylation via adenylyl cyclase/protein kinase A, selective adenylyl cyclase subtype activators may be utilized in future chemotherapy to regulate CYP activity as a switch in a tumor tissue-specific manner.

Cite this article as:

Yoshihiro Ishikawa , Sayaka Suzuki , Koji Otsu , Coskun Ulucan , Kousaku Iwatsubo and Haruki Eguchi , cAMP-Mediated Regulation of CYP Enzymes and Its Application in Chemotherapy, Drug Metabolism Letters 2007; 1 (3) . https://dx.doi.org/10.2174/187231207781369744