cAMP-Mediated Regulation of CYP Enzymes and Its Application in Chemotherapy

, Yoshihiro Ishikawa; , Sayaka Suzuki; , Koji Otsu; , Coskun Ulucan; , Kousaku Iwatsubo; , Haruki Eguchi

cAMP-Mediated Regulation of CYP Enzymes and Its Application in Chemotherapy

Author(s): Yoshihiro Ishikawa, Sayaka Suzuki, Koji Otsu, Coskun Ulucan, Kousaku Iwatsubo, Haruki Eguchi

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Journal Name: Drug Metabolism Letters

Volume 1 , Issue 3 , 2007

DOI : 10.2174/187231207781369744

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Abstract:

Certain anti-cancer prodrugs are subject to cytochrome P450 (CYP)-mediated metabolism and become more active. Because CYP activity may be regulated by phosphorylation via adenylyl cyclase/protein kinase A, selective adenylyl cyclase subtype activators may be utilized in future chemotherapy to regulate CYP activity as a switch in a tumor tissue-specific manner.

Keywords: Cytochrome P450, protein kinase A, adenylyl cyclase, phosphorylation, forskolin, anti-cancer drugs

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Drug Metabolism Letters

Title: cAMP-Mediated Regulation of CYP Enzymes and Its Application in Chemotherapy

VOLUME: 1 ISSUE: 3

Author(s): Yoshihiro Ishikawa, Sayaka Suzuki, Koji Otsu, Coskun Ulucan, Kousaku Iwatsubo and Haruki Eguchi

Affiliation:Cardiovascular Research Institute,Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.

Keywords:Cytochrome P450, protein kinase A, adenylyl cyclase, phosphorylation, forskolin, anti-cancer drugs

Abstract: Certain anti-cancer prodrugs are subject to cytochrome P450 (CYP)-mediated metabolism and become more active. Because CYP activity may be regulated by phosphorylation via adenylyl cyclase/protein kinase A, selective adenylyl cyclase subtype activators may be utilized in future chemotherapy to regulate CYP activity as a switch in a tumor tissue-specific manner.

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Yoshihiro Ishikawa, Sayaka Suzuki, Koji Otsu, Coskun Ulucan, Kousaku Iwatsubo and Haruki Eguchi, “ cAMP-Mediated Regulation of CYP Enzymes and Its Application in Chemotherapy”, Drug Metabolism Letters (2007) 1: 176. https://doi.org/10.2174/187231207781369744

DOI https://doi.org/10.2174/187231207781369744	Print ISSN 1872-3128
Publisher Name Bentham Science Publisher	Online ISSN 1874-0758

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VOLUME: 1
ISSUE: 3
Year: 2007

Page: [176 - 178]
Pages: 3
DOI: 10.2174/187231207781369744
Price: $58

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