Heat Shock Proteins And Neuroprotection

Author(s): Seema Trivedi

Journal Name: Recent Patents on DNA & Gene Sequences
Continued as Recent Advances in DNA & Gene Sequences

Volume 1 , Issue 2 , 2007


Heat shock proteins (HSPs) (also known as stress proteins) protect the cells from damages caused due to different stresses like heat, injury, chemical induced toxicity, etc. Some HSPs can act as molecular chaperones to help in correct folding of proteins or directing misfolded proteins for degradation. This action prevents toxic accumulation of proteins in cells that can otherwise lead to damage and then death. Correct folding of proteins is essential for all cells but in particular, it is known that improper folding of proteins in neurons can lead to diseases like Alzheimers, Parkinsons, polyglutamine (polyQ) diseases etc. This review focuses on patents that deal with direct or indirect applications of HSPs to prevent neurodegeneration or diagnosing neuropathy.

Keywords: Heat Shock Protein (HSP), neuroprotection, antigen, vaccine, enhanced levels, transcription factor

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Article Details

Year: 2007
Published on: 01 March, 2012
Page: [134 - 137]
Pages: 4
DOI: 10.2174/187221507780887054
Price: $65

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