Abstract
In the HIV infection, the short time-scale between the HIV-induced cardiovascular events and the onset of antiretroviral therapy elicits a thrombophilic co-factor that worsens the induced atherosclerosis. We compared the factor VIII plasma activity, previously implicated in arterial and venous thrombosis, with a surrogate marker of atherosclerosis, the carotid intima-media thickness, and with the usual atherosclerosis risk factors in 154 HIV infected outpatients. The FVIII plasma activity is significantly associated with the carotid intima-media thickness and, strongly, with blood glucose and triglycerides levels. A raised FVIII plasma activity is an important feature of the metabolic syndrome and a putative co-factor of HAART induced cardiovascular events. Thus the prevention of the HAARTinduced cardio-vascular events should probably not be exclusively focused on atherosclerosis but likewise on the thrombus formation process.
Keywords: highly active antiretroviral therapy, FVIII plasma levels, Protease Inhibitors, cardiovascular events, CD4 count
Current HIV Research
Title: Correlations Between Carotid IMT, Factor VIII Activity Level and Metabolic Disturbances: A Cardio-Vascular Risk Factor in the HIV Positive Persons
Volume: 5 Issue: 3
Author(s): Luc de Saint Martin, Elisabeth Pasquier, Olivier Vandhuick, Bertrand Arnaud, Sophie Vallet, Jerome Duchemin, Veronique Bellein and Luc Bressollette
Affiliation:
Keywords: highly active antiretroviral therapy, FVIII plasma levels, Protease Inhibitors, cardiovascular events, CD4 count
Abstract: In the HIV infection, the short time-scale between the HIV-induced cardiovascular events and the onset of antiretroviral therapy elicits a thrombophilic co-factor that worsens the induced atherosclerosis. We compared the factor VIII plasma activity, previously implicated in arterial and venous thrombosis, with a surrogate marker of atherosclerosis, the carotid intima-media thickness, and with the usual atherosclerosis risk factors in 154 HIV infected outpatients. The FVIII plasma activity is significantly associated with the carotid intima-media thickness and, strongly, with blood glucose and triglycerides levels. A raised FVIII plasma activity is an important feature of the metabolic syndrome and a putative co-factor of HAART induced cardiovascular events. Thus the prevention of the HAARTinduced cardio-vascular events should probably not be exclusively focused on atherosclerosis but likewise on the thrombus formation process.
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Cite this article as:
de Saint Martin Luc, Pasquier Elisabeth, Vandhuick Olivier, Arnaud Bertrand, Vallet Sophie, Duchemin Jerome, Bellein Veronique and Bressollette Luc, Correlations Between Carotid IMT, Factor VIII Activity Level and Metabolic Disturbances: A Cardio-Vascular Risk Factor in the HIV Positive Persons, Current HIV Research 2007; 5 (3) . https://dx.doi.org/10.2174/157016207780636498
DOI https://dx.doi.org/10.2174/157016207780636498 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
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Management of HIV: Management of HIV: old challenges and new needs
The aim of this thematic issue is to provide the most recent updates regarding the effective management of HIV infection. Antiretroviral therapy (ART) has significantly decreased HIV-related mortality, leading to an enhancement in the quality of life and life expectancy for people living with HIV (PLWH). Despite the numerous advancements ...read more
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