Abstract
A variety of mechanisms of innate immunity that protect organisms from retroviral infections, including HIV, are known. Lentiviruses express viral infectivity factor (Vif) protein that has the ability to counter antiviral activity exhibited by the recently discovered host cytidine deaminases APOBEC3G and 3F. Although these host factors are present in diverse mammalian species and have been shown to act against various organisms, their importance in HIV infection has been highlighted because of their suggested activities against HIV in vivo and the strong conservation of the HIV vif gene encoding the Vif protein capable of countering this innate activity. The main purpose of this review is to provide a detailed overview on HIV-specific interaction of APOBEC3 subfamily of proteins and discuss its potential role in HIV pathogenesis.
Keywords: cytidine deaminases, Vif Interaction, APOBEC3A, Activated CD4, HIV replication
Current HIV Research
Title: Interaction Between HIV-1 and APOBEC3 Sub-Family of Proteins
Volume: 4 Issue: 4
Author(s): Maria E. Arriaga, Jillian Carr, Peng Li, Bin Wang and Nitin K. Saksena
Affiliation:
Keywords: cytidine deaminases, Vif Interaction, APOBEC3A, Activated CD4, HIV replication
Abstract: A variety of mechanisms of innate immunity that protect organisms from retroviral infections, including HIV, are known. Lentiviruses express viral infectivity factor (Vif) protein that has the ability to counter antiviral activity exhibited by the recently discovered host cytidine deaminases APOBEC3G and 3F. Although these host factors are present in diverse mammalian species and have been shown to act against various organisms, their importance in HIV infection has been highlighted because of their suggested activities against HIV in vivo and the strong conservation of the HIV vif gene encoding the Vif protein capable of countering this innate activity. The main purpose of this review is to provide a detailed overview on HIV-specific interaction of APOBEC3 subfamily of proteins and discuss its potential role in HIV pathogenesis.
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Cite this article as:
E. Arriaga Maria, Carr Jillian, Li Peng, Wang Bin and K. Saksena Nitin, Interaction Between HIV-1 and APOBEC3 Sub-Family of Proteins, Current HIV Research 2006; 4 (4) . https://dx.doi.org/10.2174/157016206778560063
DOI https://dx.doi.org/10.2174/157016206778560063 |
Print ISSN 1570-162X |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4251 |
Call for Papers in Thematic Issues
Management of HIV: Management of HIV: old challenges and new needs
The aim of this thematic issue is to provide the most recent updates regarding the effective management of HIV infection. Antiretroviral therapy (ART) has significantly decreased HIV-related mortality, leading to an enhancement in the quality of life and life expectancy for people living with HIV (PLWH). Despite the numerous advancements ...read more
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