Magnetic Nanoparticles Catalyzed N-Tert-Butoxycarbonylation of Amines and Amine Derivatives

Author(s): Jafar Akbari, Soghra B. Sajirani, Jafar M. Nezhad, Akbar Heydari

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 3 , 2012

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A simple and efficient protocol for the chemoselective mono-N-Boc protection of various structurally diverse amines with di-tert-butyl dicarbonate using magnetically recoverable γ-Fe2O3@SiO2 nanoparticles is reported. The catalyst can be easily recovered and recycled without a significant loss in the catalytic activity. No competitive side reactions, such as formation of isocyanate, urea, oxazolidinone, and N,N-di-Boc derivatives were obsereved.

Keywords: (Boc)2O, chemoselective, magnetic nanoparticles, protection, recycling, biotechnology, tert-butoxycarbonyl, amine, magnetic field, nanocatalysis

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Article Details

Year: 2012
Page: [165 - 168]
Pages: 4
DOI: 10.2174/157017812800167510

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