Cardiovascular risk factors are associated with coronary artery disease (CAD) and with cognitive dysfunction.
However, the precise pathogenic mechanisms responsible for this association remain elusive. In the present study, CAD
patients with cognitive impairment showed significantly higher platelet activation compared with CAD patients without
cognitive impairment. In addition, we identified platelet activity to be a significant independent predictor for the severity
of cognitive impairment in these patients. We discuss the link between platelet hyperactivity and dementia (including
Alzheimer`s disease) based on the literature and our findings. We also discuss the potential mechanisms involved. This
link may become a therapeutic option.
Keywords: Coronary artery disease, platelet activation, vascular cognitive impairment, dementia, treatment targets.
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