Role of APP and Aβ in Synaptic Physiology

Author(s): Zilai Wang, Li Yang, Hui Zheng

Journal Name: Current Alzheimer Research

Volume 9 , Issue 2 , 2012

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Alzheimers disease (AD) is the most common cause of dementia in aging populations. Although amyloid plaques are the hallmark of AD, loss of synapses and synaptic dysfunction are closely associated with the duration and severity of cognitive impairment in AD patients. Amyloid precursor protein (APP) and its cleavage products including Aβ have been suggested as homeostatic regulators of synaptic activity. APP manipulation and Aβ application, in vitro and in vivo, affect synapse formation and synaptic transmission. Moreover, synaptic dysfunction and learning deficits precede Aβ plaque deposition, suggesting that synaptic alterations may underlie the initial development of the disease. Because of the pivotal role of APP and Aβ in AD pathogenesis, it is essential to understand how APP and Aβ modulate synaptic function. Here, we review the roles that APP and Aβ play at the synapses, with particular focus on recent findings for the importance of APP in synaptogenesis and synaptic function.

Keywords: AD, APP, A, synaptogenesis, neuronal activity, synaptic transmission, cholinergic, glutamatergic, GABAergic

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Article Details

Year: 2012
Page: [217 - 226]
Pages: 10
DOI: 10.2174/156720512799361691
Price: $65

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