Modulation of Signal-Transducing Function of Neuronal Membrane Na+,K by Endogenous Ouabain and Low-Power Infrared Radiation Leads to Pain Relief

Author(s): Ekaterina V. Lopatina, Igor L. Yachnev, Valentina A. Penniyaynen, Vera B. Plakhova, Svetlana A. Podzorova, Tatiana N. Shelykh, Ilya V. Rogachevsky, Irina P. Butkevich, Viktor A. Mikhailenko, Anna V. Kipenko, Boris V. Krylov

Journal Name: Medicinal Chemistry

Volume 8 , Issue 1 , 2012

Become EABM
Become Reviewer
Call for Editor


Effects of infrared (IR) radiation generated by a low-power Co2-laser on sensory neurons of chick embryos were investigated by organotypic culture method. Low-power IR radiation firstly results in marked neurite suppressing action, probably induced by activation of Na+,K+-ATPase signal-transducing function. A further increase in energy of radiation leads to stimulation of neurite growth. We suggest that this effect is triggered by activation of Na+,K+-ATPase pumping function. Involvement of Na+,K+-ATPase in the control of the transduction process was proved by results obtained after application of ouabain at very low concentrations. Physiological significance of low-power IR radiation and effects of ouabain at nanomolar level was investigated in behavioral experiments (formalin test). It is shown that inflammatory pain induced by injection of formalin is relieved both due to ouabain action and after IR irradiation.

Keywords: Na+,K+-ATPase, signal-transducing function, patch-clamp, organotypic tissue culture, formalin test, ouabain, infrared radiation, cardiac myocytes, smooth muscle cells, nerve tissue

open access plus

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2012
Page: [33 - 39]
Pages: 7
DOI: 10.2174/157340612799278531

Article Metrics

PDF: 25