Abstract
5-Substituted uracils were reported to be important core structure of diverse therapeutics. Herein, novel mixed ligand transition metal (Mn, Cu, Ni) complexes of 5-iodouracil (5Iu) with 8-hydroxyquinoline or 8HQ (1-3) and 5- nitrouracil (5Nu) with 8HQ (4-6) have been synthesized. The metal complexes 1-6 exert significant cytotoxicity against HepG2, A-549, HuCCA-1 and MOLT-3 cell lines. Particularly, the cytotoxicities of tested complexes against HepG2 cells show their IC50 values lower than the reference drug. Cu complex of 5Nu (5Nu-Cu-8HQ, 5) is the most potent and promising cytotoxic compound. Mn complex of 5Iu (5Iu-Mn-8HQ, 1) is shown to be the most potent antioxidant. This finding reveals the application of using simple and commercially available bioactive ligands like 5Iu, 5Nu and 8HQ for the design and construction of new lead compounds with significant and promising bioactivities.
Keywords: 5-iodouracil, 5-nitrouracil, Metal complex, SOD and cytotoxic activities, Uracil Derivatives, anticancer drug, antioxidant activity, Melting points, Gibco and Hyclone laboratories, 8HQ, olefinic electron donor, Cytotoxic Activity, Superoxide Dismutase, Antioxidative Activity
Letters in Drug Design & Discovery
Title: Metal Complexes of Uracil Derivatives with Cytotoxicity and Superoxide Scavenging Activity
Volume: 9 Issue: 3
Author(s): Supaluk Prachayasittikul, Apilak Worachartcheewan, Ratchanok Pingaew, Thummaruk Suksrichavalit, Chartchalerm Isarankura-Na-Ayudhya, Somsak Ruchirawat and Virapong Prachayasittikul
Affiliation:
Keywords: 5-iodouracil, 5-nitrouracil, Metal complex, SOD and cytotoxic activities, Uracil Derivatives, anticancer drug, antioxidant activity, Melting points, Gibco and Hyclone laboratories, 8HQ, olefinic electron donor, Cytotoxic Activity, Superoxide Dismutase, Antioxidative Activity
Abstract: 5-Substituted uracils were reported to be important core structure of diverse therapeutics. Herein, novel mixed ligand transition metal (Mn, Cu, Ni) complexes of 5-iodouracil (5Iu) with 8-hydroxyquinoline or 8HQ (1-3) and 5- nitrouracil (5Nu) with 8HQ (4-6) have been synthesized. The metal complexes 1-6 exert significant cytotoxicity against HepG2, A-549, HuCCA-1 and MOLT-3 cell lines. Particularly, the cytotoxicities of tested complexes against HepG2 cells show their IC50 values lower than the reference drug. Cu complex of 5Nu (5Nu-Cu-8HQ, 5) is the most potent and promising cytotoxic compound. Mn complex of 5Iu (5Iu-Mn-8HQ, 1) is shown to be the most potent antioxidant. This finding reveals the application of using simple and commercially available bioactive ligands like 5Iu, 5Nu and 8HQ for the design and construction of new lead compounds with significant and promising bioactivities.
Export Options
About this article
Cite this article as:
Prachayasittikul Supaluk, Worachartcheewan Apilak, Pingaew Ratchanok, Suksrichavalit Thummaruk, Isarankura-Na-Ayudhya Chartchalerm, Ruchirawat Somsak and Prachayasittikul Virapong, Metal Complexes of Uracil Derivatives with Cytotoxicity and Superoxide Scavenging Activity, Letters in Drug Design & Discovery 2012; 9 (3) . https://dx.doi.org/10.2174/157018012799129918
DOI https://dx.doi.org/10.2174/157018012799129918 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Strategies for Targeting the Multidrug Resistance-1 (MDR1)/P-gp Transporter in Human Malignancies
Current Cancer Drug Targets HIV-1 Infected Patients have Antibodies Recognizing Folded Tat
Infectious Disorders - Drug Targets Pyrroles and Fused Pyrroles: Synthesis and Therapeutic Activities
Mini-Reviews in Organic Chemistry Active Targeted Drug Delivery for Microbes Using Nano-Carriers
Current Topics in Medicinal Chemistry Ribozymes in the Age of Molecular Therapeutics
Current Molecular Medicine Transforming Growth Factor-β Signaling in Motor Neuron Diseases
Current Molecular Medicine 1,2,4-Triazine Chemistry Part III: Synthetic Strategies to Functionalized Bridgehead Nitrogen Heteroannulated 1,2,4-Triazine Systems and their Regiospecific and Pharmacological Properties
Current Organic Synthesis Fused Xanthone Derivatives as Antiproliferative Agents
Anti-Cancer Agents in Medicinal Chemistry Pharmacological Inhibition of Protein Tyrosine Phosphatase 1B: A Promising Strategy for the Treatment of Obesity and Type 2 Diabetes Mellitus
Current Medicinal Chemistry Multilocular Thymic Cyst in a Patient with Untreated HIV/AIDS: Case Report and Review of the Literature
Current HIV Research Growth and Trophic Factors, pH and the Na+/H+ Exchanger in Alzheimers Disease, Other Neurodegenerative Diseases and Cancer: New Therapeutic Possibilities and Potential Dangers
Current Alzheimer Research MATra - Magnet Assisted Transfection: Combining Nanotechnology and Magnetic Forces to Improve Intracellular Delivery of Nucleic Acids
Current Pharmaceutical Biotechnology Acute Hypersensitivity Reactions to Chemotherapy Agents: An Overview
Inflammation & Allergy - Drug Targets (Discontinued) GIST and Breast Cancer: 3 Case Reports and a Review of the Literature
Current Cancer Therapy Reviews Antisense Therapy for Cardiovascular Diseases
Current Pharmaceutical Design Anti-Apoptotic Actions of Insulin-Like Growth Factors: Lessons from Development and Implications in Neoplastic Cell Transformation
Current Pharmaceutical Design Nitric Oxide in Cancer Therapeutics: Interaction with Cytotoxic Chemotherapy
Current Pharmaceutical Design A Novel Boolean Network for Analyzing the p53 Gene Regulatory Network
Current Bioinformatics State of Art and Recent Developments of Anti-Cancer Strategies Based on TRAIL
Recent Patents on Anti-Cancer Drug Discovery α-Halogenoacrylic Derivatives of Antitumor Agents
Mini-Reviews in Medicinal Chemistry