Tetrakis(acetonitrile)copper(I) Hexafluorophosphate as an Efficient Catalyst for the Synthesis of Triazolo[1,2-a]indazole-1,3,8-trione and 2Hindazolo[2,1-b]phthalazine-trione Derivatives

Author(s): Davood Azarifar, Razieh Nejat-Yami, Zahra Akrami, Fatemeh Sameri, Saadi Samadi

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 2 , 2012


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Abstract:

Tetrakis(acetonitrile)copper(I) hexafluorophosphate, [Cu(CH3CN)4]PF6, was explored as an efficient catalyst to promote the three-component reaction of aryl aldehydes, dimedone and urazole or phthalhydrazide to afford the corresponding triazolo[1,2-a]indazole-1,3,8-trione and 2H-indazolo[2,1-b]phthalazine-trione derivatives respectively in high yields. The reactions were conducted at 80-100 °C under solvent-free conditions. The catalyst was easily prepared from available and inexpensive materials and was quantitatively recovered from the reaction by simple filtration and reused for a number of cycles with almost consistent activity

Keywords: 2H-Indazolo[2, 1-b]phthalazine-trione, dimedone, phthalhydrazide, tetrakis(acetonitrile)copper(I)hexafluorophosphate, triazolo[1, 2-a]indazole-1, 3, 8-trione, urazole, phthalazine, pyrazoles, multi-component, vasorelaxant

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Article Details

VOLUME: 9
ISSUE: 2
Year: 2012
Published on: 01 March, 2012
Page: [128 - 132]
Pages: 5
DOI: 10.2174/157017812800221807
Price: $65

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