Triphenylphosphine Catalyzed, One-Pot, Multicomponent Synthesis of Spirooxindoles

Author(s): Syed Riyaz, A. Naidu, Pramod K. Dubey

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 2 , 2012

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Multicomponent reaction involving isatin (1), malononitrile (2), and dimedone (3), in the presence of triphenylphosphine as an efficient catalyst in the eco-friendly solvent ethanol, results in the formation of spirooxindole derivatives 4 i.e 2-Amino-5-oxo-7,7-dimethyl spiro[(4H)-5,6,7,8-tetrahydrochromene-4,3-(3H)-indol]-(10H)-2-onecarbonitrile. The reaction proceeds smoothly under mild conditions and the products are obtained in good to excellent yields. This method is applicable to a variety of isatin derivatives.

Keywords: Cyclo addition, multicomponent reaction, spirooxindoles, triphenylphosphine, condensation, ethanol, eco-friendly solvent, acetonitrile, methanol, ethyl acetate

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Article Details

Year: 2012
Page: [101 - 105]
Pages: 5
DOI: 10.2174/157017812800221771

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