Abstract
Acetylcholinesterase (AChE), a member of the α/β-hydrolase fold superfamily of proteins, is a serine hydrolase responsible for the hydrolysis of the well studied neurotransmitter acetylcholine (ACh). However, it is becoming clear that AChE has a range of actions other than this ‘classical’ role. Non-classical AChE functions have been identified in apoptosis, stress-responses, neuritogenesis, and neurodegeneration. Furthermore, these non-classical roles are attributable not only to the native protein, which appears to act as a mediary binding protein under a number of circumstances, but also to peptides cleaved from the parent protein. Peptides cleaved from AChE can act as independent signalling molecules. Here we discuss the implications of non-hydrolytic functions of this multi-tasking protein.
Keywords: Acetylcholinesterase, adhesion, apoptosis, neurogenesis, non-hydrolytic function, signalling peptide, synaptic, exons, Tetramers, 3D X-ray structure, glycophosphatidylinositol (GPI)
Protein & Peptide Letters
Title: From Protein to Peptides: a Spectrum of Non-Hydrolytic Functions of Acetylcholinesterase
Volume: 19 Issue: 2
Author(s): Amy C. Halliday and Susan A. Greenfield
Affiliation:
Keywords: Acetylcholinesterase, adhesion, apoptosis, neurogenesis, non-hydrolytic function, signalling peptide, synaptic, exons, Tetramers, 3D X-ray structure, glycophosphatidylinositol (GPI)
Abstract: Acetylcholinesterase (AChE), a member of the α/β-hydrolase fold superfamily of proteins, is a serine hydrolase responsible for the hydrolysis of the well studied neurotransmitter acetylcholine (ACh). However, it is becoming clear that AChE has a range of actions other than this ‘classical’ role. Non-classical AChE functions have been identified in apoptosis, stress-responses, neuritogenesis, and neurodegeneration. Furthermore, these non-classical roles are attributable not only to the native protein, which appears to act as a mediary binding protein under a number of circumstances, but also to peptides cleaved from the parent protein. Peptides cleaved from AChE can act as independent signalling molecules. Here we discuss the implications of non-hydrolytic functions of this multi-tasking protein.
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Cite this article as:
C. Halliday Amy and A. Greenfield Susan, From Protein to Peptides: a Spectrum of Non-Hydrolytic Functions of Acetylcholinesterase, Protein & Peptide Letters 2012; 19 (2) . https://dx.doi.org/10.2174/092986612799080149
DOI https://dx.doi.org/10.2174/092986612799080149 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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