Dendritic Cells in Autoimmune Liver Diseases

Author(s): Masanori Abe, Yoichi Hiasa, Morikazu Onji

Journal Name: Current Immunology Reviews

Volume 8 , Issue 1 , 2012

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Dendritic cells (DC) are professional antigen presenting cells that maintain immune tolerance to self-antigens by controlling the pathogenicity of autoreactive T cells, and a lack of immune tolerance against self-antigens results in autoimmune diseases. Therefore, DCs play an essential role in the induction and/or maintenance of autoimmunity. In the present review, we focus on the role of DCs in the pathogenesis of autoimmune liver diseases. In addition, recent developments in DC-based immunotherapy using regulatory (tolerogenic) DCs in autoimmune diseases will be discussed.

Keywords: Autoimmune liver disease, dendritic cells, tolerance, antigen presenting cells, autoimmune diseases, immunotherapy, autoimmune hepatitis, biliary cirrhosis, IgG4-Related Sclerosing Cholangitis, Regulatory dendritic cells

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Article Details

Year: 2012
Page: [23 - 27]
Pages: 5
DOI: 10.2174/157339512798991281

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PDF: 12