Matrix Systems for siRNA Delivery

Author(s): B. Naeye, K. Raemdonck, K. Remaut, J. Demeester, S. C. De Smedt

Journal Name: Current Topics in Medicinal Chemistry

Volume 12 , Issue 2 , 2012

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Over the last decade, considerable effort has been put in the implementation of RNA interference (RNAi) as a treatment for various disorders. As RNAi occurs in the cytoplasm of cells, it is imperative that RNAi mediators such as small interfering RNA (siRNA) cross several extracellular and intracellular barriers to reach this site of action. Among the extensive range of proposed delivery systems for siRNA, matrix systems possess interesting properties to promote the delivery of siRNA to a target tissue. In this review, a number of recently developed matrix and hybrid systems for siRNA delivery are discussed.

Keywords: delivery, hybrid, matrix, microgel, nanogel, RNAi, siRNA, cytoplasm of cells, target tissue, hybrid systems, conventional small molecule pharmaceutics, endosomal pathway, Omethyl ribonucleosides, bioconjugation, fast glomerular filtration

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Article Details

Year: 2012
Page: [89 - 96]
Pages: 8
DOI: 10.2174/156802612798919150
Price: $65

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PDF: 8