A One Pot Green Synthesis of 3,4 Dihydropyrimidin-2-(1H)-ones/Thiones Catalyzed By MgO-ZrO2 Under Solvent-Free Conditions

Author(s): Manoj B. Gawande, Deepak M. Nagrik, Damodar M. Ambhore

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 1 , 2012

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An efficient green synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones (DHPMs) using MgO/ZrO2 as heterogeneous basic catalyst from an aldehyde, β-keto ester and urea/thiourea under solvent-free conditions is described. A variety of aldehydes were studied with β-keto ester and urea/thiourea giving good to excellent yield of corresponding 3,4-dihydropyrimidin-2-(1H)-ones/thiones. This protocol has advantage of excellent yield, reusability, inexpensive and short reaction time at room temperature. The synthesized catalyst can be reused up to 5 consecutive cycles without any decrease in the yield.

Keywords: DHPMs, green synthesis, multicomponent reactions (MCRs), MgO-ZrO2, medicinal chemistry, alkaloids, Biginelli dihydropyrimidinones, Hantzsh type, batzelladine, anticancer drugs

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Article Details

Year: 2012
Page: [12 - 18]
Pages: 7
DOI: 10.2174/157017812799303980

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