SCYPPred: A Web-Based Predictor of SNPs for Human Cytochrome P450

Author(s): Li Li, Dong-Qing Wei, Jing-Fang Wang, Kuo-Chen Chou

Journal Name: Protein & Peptide Letters

Volume 19 , Issue 1 , 2012

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Abstract:

Human cytochrome P450(CYP 450) enzymes mediate over 60% of the phase I-dependent metabolism of clinical drugs. They are also known for the polymorphism functions that have significant impacts on the enzyme activities. In this study, a web-server called SCYPPred was developed for predicting human cytochrome P450 SNPs (Single Nucleotide Polymorphisms) based on the SVM flanking sequence method; SCYPPred can rapidly yield the desired results by using the amino acid sequences information alone. The web-server is accessible to the public at http://snppred.sjtu.edu.cn. Hopefully SCYPPred could be a useful bioinformatics tool for elucidating the mutation probability of a specific CYP450 enzyme.

Keywords: Cytochrome P450, SNPs, SVM, Mutation Probability, Human cytochrome, SCYPPred, SVM flanking, hemoproteins, archaea, DNA-sequence, Vector encoding, KEGG, RBF, FN, Single Nucleotide Polymorphisms, benchmark dataset

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Article Details

VOLUME: 19
ISSUE: 1
Year: 2012
Page: [57 - 61]
Pages: 5
DOI: 10.2174/092986612798472785

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