Recent Applications of the Simple Hydrocarbon Cyclooctatetrene as a Starting Material for Complex Molecule Synthesis

Author(s): Kevin W. Glaeske, William A. Donaldson

Journal Name: Mini-Reviews in Organic Chemistry

Volume 9 , Issue 1 , 2012

Become EABM
Become Reviewer


Cyclooctatetraene [COT], a simple non-aromatic cyclic polyene, is capable of undergoing a variety of oxidation and cycloaddition reactions to afford polycyclic structures. In addition, complexation of COT or the cycloaddition products with transition metals facilitates bond formation. Recent developments in the reactivity of COT and application to the synthesis of naturally occurring and non-naturally occurring compounds is reviewed.

Keywords: Cyclooctatetraene, oxidation, Cycloaddition, synthesis, complex molecule, epoxide products, pentacycloanammoxic, cyclooctitols, carbonylation reactions, B-Allose

open access plus

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2012
Page: [31 - 43]
Pages: 13
DOI: 10.2174/157019312799079983

Article Metrics

PDF: 45