One-Pot Three-Component Reaction for Synthesis of Highly Substituted Pyrazolo[1,2-a][1,2,4]triazole Derivatives

Author(s): Seyed S. Sajadikhah, Malek T. Maghsoodlou, Nourallah Hazeri, Sayyed M. Habibi-Khorassani

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 10 , 2011

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A straightforward, simple and efficient method is described for the synthesis of pyrazolo[1,2-a][1,2,4]triazole derivates via one-pot three-component reaction between isocyanides, dialkyl acetylenedicarboxylate and 4-phenyl urazole (as a NH-acid) in acetone without using any catalyst at ambient temperature. This method offers several advantages such as high yield of products, easy work-up procedure and mild reaction conditions.

Keywords: Dialkyl acetylenedicarboxylate, isocyanide, multi-component reaction, pyrazolo[1,2-a][1,2,4]triazole, urazole, anti-inflammatory, anti-microbial, anti-hypoxic, analgesic, antibacterial

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Article Details

Year: 2011
Page: [743 - 748]
Pages: 6
DOI: 10.2174/157017811799304188
Price: $65

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