Synthesis and Biological Evaluation of Some Novel Thiazolylhydrazinomethylideneferrocenes as Antimicrobial Agents

Author(s): Navneet Chandak, Pawan Kumar, Chetan Sharma, Kamal R. Aneja, Pawan K. Sharma

Journal Name: Letters in Drug Design & Discovery

Volume 9 , Issue 1 , 2012

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Some novel thiazolylhydrazinomethylideneferrocenes 4 and 5 bearing phenyl and coumarin analogues respectively at position-4 of 1,3-thiazole were synthesized using established procedures and were evaluated for their in vitro antibacterial activity against four pathogenic bacterial strains namely, S. aureus, B. subtilis (Gram-positive), E. coli, P. aeruginosa (Gram-negative), and in vitro antifungal activity against two pathogenic fungal strains namely, A. niger and A. flavus. Four tested compounds, 4a, 4d, 4e and 4f exhibited moderate antibacterial activity against Gram-positive bacteria and 4e exhibited moderate antifungal activity against the tested fungi. However, none of the compounds showed any activity against Gram-negative bacteria.

Keywords: Antibacterial activity, Antifungal activity, Thiazoles, Coumarin, Thiazolylhydrazinomethylideneferrocenes, antimicrobial agents, S. aureus, B. subtilis, Gram-positive, E. coli, P. aeruginosa, A. flavus, Gram-negative bacteria, xanthine oxidase

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Article Details

Year: 2012
Published on: 01 March, 2012
Page: [63 - 68]
Pages: 6
DOI: 10.2174/157018012798192973

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