Novel Hexahydropyridoindole Derivative as Prospective Agent Against Oxidative Damage in Pancreatic βCells

Author(s): Lucia Rackova, Ahmet Cumaoglu, E. Umit Bagrιacιk, Milan Stefek, Pierre Maechler, Cimen Karasu

Journal Name: Medicinal Chemistry

Volume 7 , Issue 6 , 2011

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The potential protective effect of (±)-8-methoxy-1,3,4,4a,5,9b-hexahydro-pyrido[4,3-b]indole-2-carboxylic acid ethyl ester (II) was assessed against hydrogen peroxide (H2O2)-cytotoxicity in rat pancreatic INS-1E β cells and compared with the effect of the related pyridoindole, stobadine (I), a promising indole-type reference antioxidant. Only pre-treatment with the compound (II) led to a significant preservation of the metabolic and secretory functions of the cells exposed to H2O2.

The caspase-9 and -3 activities, as well as the early apoptotic changes of plasma membrane, were suppressed in the cells pre-incubated with both of compounds tested. However, only pyridoindole (II) inhibited profoundly the time-delayed apoptotic changes,

These results suggest that pyridoindole (II) characterized by enhanced intrinsic antioxidant efficiency, may protect ?? cells against cytotoxic effects of H2O2, involved in the development of both type 1 and type 2 diabetes.

Keywords: Indole antioxidant, pancreatic cells, oxidative stress, diabetes, hexahydro-pyrido, (H2O2)-cytotoxicity, promising indole-type, metabolic and secretory functions of the cells, exposed to H2O2, pyridoindole (II)

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Article Details

Year: 2011
Page: [711 - 717]
Pages: 7
DOI: 10.2174/157340611797928370
Price: $65

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