Synthesis and Bioactivities of 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors

Author(s): Yubin Wang, Hai Qian, Jinpei Zhou, Huibin Zhang, Jianfeng Ji, Wenlong Huang

Journal Name: Medicinal Chemistry

Volume 7 , Issue 6 , 2011

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Abstract:

Twenty-four 2-azetidinone derivatives have been designed and synthesized as cholesterol absorption inhibitors. All new compounds were evaluated for their activity to inhibit cholesterol absorption in hamsters, and most of them showed considerable effects in lowering the levels of total cholesterol in the serum, especially compound 2d, 4a, 4f, 4i and 4j.

Keywords: 2-Azetidinones, cholesterol absorption inhibitor, synthesis, bioactivities, hamsters, cardiovascular research, coronary heart disease (CHD), exogenous pathways, 3-methylglutaryl, 3-hydroxy

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Article Details

VOLUME: 7
ISSUE: 6
Year: 2011
Page: [534 - 542]
Pages: 9
DOI: 10.2174/157340611797928271
Price: $65

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