Synthesis of Sildenafil Citrate and Process Related Impurities

Author(s): Indukuri V.S. Kumar, Gorantla S. Ramanjaneyulu, Vurimindi H. Bindu

Journal Name: Letters in Organic Chemistry

Volume 8 , Issue 9 , 2011

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Synthesis of Sildenafil by the O-alkylation of 5-[2-hydroxy-5-(4-methylpiperazin-1-ylsulphonyl)phenyl]-1- methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo-[4,3-d]pyrimidin-7-one 8 proved difficult because concomitant alkylation of the pyrimidine moity also occurred. The selective O-alkylation was carried by DCC assisted decarboxilative etherification of the carbonate 9.

Keywords: Decarboxilative etherification, sildenafil citrate, process impurities, piperazine, cyclic guanosine monophosphate, phenol, O-alkylation, silica gel, chromatography, alkylarylcarbonates

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Article Details

Year: 2011
Page: [668 - 673]
Pages: 6
DOI: 10.2174/157017811799304304
Price: $65

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