Antioxidant Evaluation of Some Semicarbazide, 1,2,4-Triazolone and Pyrazolone Derivatives

Author(s): Monika Pitucha, Renata Nowak

Journal Name: Letters in Drug Design & Discovery

Volume 8 , Issue 10 , 2011

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1,2,4-Triazoles, pyrazoles and semicarbazides possessing heterocyclic ring 1-14 were synthesized as compounds with interesting pharmacological profiles. All were investigated in vitro for their antioxidant activity. Some compounds showed significant effect in the above assay. The most promising was a group of pyrazolone.

The effect was dependent mainly on the substituent on the amide group. It was found that compounds 8 and 10 showed the highest antioxidant capacity comparable with the widely used reference, antioxidant 6-hydroxy-2,5,7,8- tetramethylchroman-2-carboxylic acid (Trolox).

Keywords: Antioxidant activity, Pyrazoles, Semicarbazides, 1, 2, 4-Triazoles, Trolox, Tongguan capsule (TGC), coronary heart disease (CHD), Traditional Chinese Medicine (TCM), Molecular Mechanism, Computational Pharmacology Methods, Salvia, Gaussin distribution, Lipinski's “rule of five”, Astragalus

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Article Details

Year: 2011
Page: [1004 - 1008]
Pages: 5
DOI: 10.2174/157018011797655188
Price: $65

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