Synthesis of Cinnamide Dimers as Potential Antibacterial and Antifungal Agents

Author(s): Ahmed Kamal, G. Ramakrishna, P. Raju, A. V. Subba Rao, Joveeta Joseph, B. Siddhardha, U. S.N. Murty

Journal Name: Letters in Drug Design & Discovery

Volume 8 , Issue 10 , 2011

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A series of new cinnamide dimers was synthesized (5a-6a) and evaluated for their antimicrobial and antifungal activity. All the compounds investigated have shown significant antimicrobial activity against gram-positive and gram-negative bacterial strains, as well as few fungal strains. The compounds having withdrawing group exhibited significant biological activity than their precursors. Moreover all the compounds containing electron withdrawing substituent showed good antimicrobial activity in comparison with the standards.

Keywords: Antibacterial, Antifungal, Cinnamide dimers, Piperazine, antimicrobial activity, antifungal activity, methicillin resistant Staphylococcus aureus (MRSA), methicillin resistant epidermidis (MRSE), vancomycin, VRE, enterococci, Crixivan, N-Boc piperazine, Aspergillus

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Article Details

Year: 2011
Page: [957 - 965]
Pages: 9
DOI: 10.2174/157018011797655205
Price: $65

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